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It turned out they shared a rare mutation blocking the leptin gene. With no leptin to curb hunger, their appetites were voracious.You are not likely to have this same gene abnormality. However air max 97 mens cheap , your leptin may not be working perfectly either. Very-low-calorie diets disrupt its appetite-taming effect, causing your appetite to run out of control. The key to keeping leptin working right is to avoid severe calorie restrictions. If you eat at least 10 calories per day per pound of your ideal weight, you are unlikely to run into serious problems.* A gene on chromosome 8 builds LPL, the key enzyme that stores fat in your cells. It waits along the walls of the tiny blood vessels that course through your body fat, and its job is to extract fat from your bloodstream and pass it into your fat cells for storage. If your LPL is doing its job a little too well, you can change this genetic tendency by choosing foods that have little or no fat in them. 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